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ML-SA5

Chemical Structure : ML-SA5

CAS No.: 2418670-70-7

ML-SA5 (TRPML1 agonist ML-SA5)

Catalog No.: PC-72043Not For Human Use, Lab Use Only.

ML-SA5 (TRPML1 agonist ML-SA5) is a potent, small molecule agonist of transient receptor potential mucolipin 1 (TRPML1/MCOLN1/ML1), dose-dependently activated whole-endolysosomal ML1 currents in DMD myoblasts with EC50 of 285±144 nM.

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Biological Activity

ML-SA5 (TRPML1 agonist ML-SA5) is a potent, small molecule agonist of transient receptor potential mucolipin 1 (TRPML1/MCOLN1/ML1), dose-dependently activated whole-endolysosomal ML1 currents in DMD myoblasts with EC50 of 285±144 nM.
ML-SA5–induced lysosomal Ca2+ release, measured with GCaMP3 imaging, in primary myotubes isolated from ML1MCK mice.
ML-SA5 ML1 agonist ML-SA5 ameliorate muscular dystrophies, facilitates sarcolemma repair to reduce muscle damage, activates TFEB to correct lysosomal insufficiency in mdx mice.

Physicochemical Properties

M.Wt 457.988
Formula C19H24ClN3O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,4-Benzenedisulfonamide, N4-[3-chloro-2-(1-piperidinyl)phenyl]-N1,N1-dimethyl-

References

1. Lu Yu, et al. Sci Adv. 2020 Feb 7;6(6):eaaz2736.

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