Chemical Structure : ML-SA5
CAS No.:
2418670-70-7
ML-SA5
(Mucolipin 1 agonist ML-SA5)
Catalog No. : PC-72043Not For Human Use, Lab Use Only.
ML-SA5 (Mucolipin 1 agonist ML-SA5) is a potent, small molecule agonist of transient receptor potential mucolipin 1 (TRPML1/MCOLN1/ML1), dose-dependently activated whole-endolysosomal ML1 currents in DMD myoblasts with EC50 of 285±144 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7204301
Biological Activity
ML-SA5 (Mucolipin 1 agonist ML-SA5) is a potent, small molecule agonist of transient receptor potential mucolipin 1 (TRPML1 /MCOLN1/ML1), dose-dependently activated whole-endolysosomal ML1 currents in DMD myoblasts with EC50 of 285±144 nM.
Physicochemical Properties
M.Wt
457.988
Formula
C19H24ClN3O4S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,4-Benzenedisulfonamide, N4-[3-chloro-2-(1-piperidinyl)phenyl]-N1,N1-dimethyl-
References
1. Lu Yu, et al. Sci Adv.
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