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Chemical Structure : AMG517
CAS No.: 659730-32-2
Catalog No.: PC-42689Not For Human Use, Lab Use Only.
AMG517 is a potent and selective vanilloid receptor TRPV1 antagonist with IC50 of 0.76 nM for hTRPV
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 10 mg | $78 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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AMG517 is a potent and selective vanilloid receptor TRPV1 antagonist with IC50 of 0.76 nM for hTRPV1.
AMG517 is effective in a rodent "on-target" biochemical challenge model (capsaicin-induced flinch, ED50 = 0.33 mg/kg p.o.).
AMG517 exhibits antihyperalgesic in a model of inflammatory pain (CFA-induced thermal hyperalgesia, MED = 0.83 mg/kg, p.o.).
| M.Wt | 430.403 | |
| Formula | C20H13F3N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 12.91 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
Acetamide, N-[4-[[6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]- |
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1. Doherty EM, et al. J Med Chem. 2007 Jul 26;50(15):3515-27.
2. Gavva NR, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):128-37.
3. Gavva NR, et al. Pain. 2008 May;136(1-2):202-10.
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