Catalog No.: PC-42017Not For Human Use, Lab Use Only.
SKF-96365 hydrochloride (SKF96365) is potent inhibitor of receptor-mediated calcium entry (RMCE) with IC50 of 8.5 and 11.7 uM for inhibition in platelets stimulated with ADP and thrombin, respectively.
SKF-96365 hydrochloride (SKF96365) is potent inhibitor of receptor-mediated calcium entry (RMCE) with IC50 of 8.5 and 11.7 uM for inhibition in platelets stimulated with ADP and thrombin, respectively.
SKF-96365 shows selectivity in blocking RMCE compared with receptor-mediated internal Ca2+ release.
SKF-96365 inhibits Store-operated Ca2+ entry (SOCE) and Icrac in the 20-30 uM range in several cell lines, and inhibits STIM1-mediated Ca2+ influx and the nuclear translocation and activation of the NFAT transcription factor in cells expressing STIM1.
SKF-96365 also blocks TRPC, voltage gated Ca2+ channel (human Cav3.1 IC50= 560 nM), potassium channels.
