Catalog No.: PC-42084Not For Human Use, Lab Use Only.
HC-067047 (HC067047) is a potent and selective TRPV4 antagonist with IC50 of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4 in cell assays, respectively.
HC-067047 (HC067047) is a potent and selective TRPV4 antagonist with IC50 of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4 in cell assays, respectively.
HC067047 displays high selectivity against a variety of ion-channel targets, including representative channels of the TRPV, TRPC, TRPA, and TRPMs.
HC067047 inhibits endogenous TRPV4-mediated response to 4α-PDH with IC50 of 22 nM.
HC067047 increases functional bladder capacity and reduces micturition frequency in WT mice and rats with cystitis without effects on bladder function.
