ML2-SA2

Chemical Structure : ML2-SA2

Catalog No.: PC-25086Not For Human Use, Lab Use Only.

ML2-SA2 is a selective, small-molecule TRPML2 channel agonist with EC50 of 6.4 uM, while inhibiting TRPML1 and TRPML3 with IC50 of 2.3 uM and 15.9 uM, respectively.

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Biological Activity

ML2-SA2 is a selective, small-molecule TRPML2 channel agonist with EC50 of 6.4 uM, while inhibiting TRPML1 and TRPML3 with IC50 of 2.3 uM and 15.9 uM, respectively.
ML2-SA2 restores channel activity and vesicle trafficking in PI(3,5)P₂-insensitive cells.
ML2-SA2 reduces Golgi accumulation, and promotes peripheral vesicle dynamics.

Physicochemical Properties

M.Wt	435.61
Formula	C21H29N3O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiophenesulfonamide, N-[(1R,2R)-2-[4-(2-methoxyphenyl)-1-piperazinyl]cyclohexyl]-, rel-

References

1. Zi-Qi Gu, et al. Biomed Pharmacother. 2025 Jul 14:189:118350.

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ML2-SA2

Biological Activity

Physicochemical Properties

References

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