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BAY-390

Chemical Structure : BAY-390

CAS No.: 2741956-55-6

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BAY-390 (BAY390)

Catalog No.: PC-49696Not For Human Use, Lab Use Only.

BAY-390 (BAY390) is a potent, selective, brain-penetrant TRPA1 inhibitor with IC50 of 16 and 63 nM for hTRPA1 and rTRPV1, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BAY-390 (BAY390) is a potent, selective, brain-penetrant TRPA1 inhibitor with IC50 of 16 and 63 nM for hTRPA1 and rTRPV1, respectively.
    BAY-390 (90 mg/kg, oral, twice daily) reversed mechanical allodynia in the spinal nerve ligation (SNL) neuropathic pain model in rats.
    BAY-390 (30 mg/kg, oral, twice daily) reduced CFA-induced inflammatory pain in rats.
    BAY-390 is an in vitro and in vivo probe to investigate the central and peripheral roles played by TRPA1 in rodent preclinical models.

    Physicochemical Properties

    M.Wt 277.26
    Formula C13H15F4NO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2R)-2-[(4-Fluorophenyl)amino]-1-(trifluoromethyl)cyclohexanol

    References

    1. Stefanie Mesch, et al. J Med Chem. 2023 Jan 26;66(2):1583-1600.

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