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Chemical Structure : BAY-390
Catalog No.: PC-49696Not For Human Use, Lab Use Only.
BAY-390 (BAY390) is a potent, selective, brain-penetrant TRPA1 inhibitor with IC50 of 16 and 63 nM for hTRPA1 and rTRPV1, respectively.
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BAY-390 (BAY390) is a potent, selective, brain-penetrant TRPA1 inhibitor with IC50 of 16 and 63 nM for hTRPA1 and rTRPV1, respectively.
BAY-390 (90 mg/kg, oral, twice daily) reversed mechanical allodynia in the spinal nerve ligation (SNL) neuropathic pain model in rats.
BAY-390 (30 mg/kg, oral, twice daily) reduced CFA-induced inflammatory pain in rats.
BAY-390 is an in vitro and in vivo probe to investigate the central and peripheral roles played by TRPA1 in rodent preclinical models.
| M.Wt | 277.26 | |
| Formula | C13H15F4NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stefanie Mesch, et al. J Med Chem. 2023 Jan 26;66(2):1583-1600.
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