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KS0365

Chemical Structure : KS0365

CAS No.: 1689577-22-7

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KS0365 (KS 0365)

Catalog No.: PC-49275Not For Human Use, Lab Use Only.

KS0365 (KS 0365) is a potent and selective activator of transient receptor potential vanilloid 3 (TRPV3) channel with EC50 of 5.08 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KS0365 (KS 0365) is a potent and selective activator of transient receptor potential vanilloid 3 (TRPV3) channel with EC50 of 5.08 uM.
    KS0365 activated recombinant and native mouse TRPV3 more potently and with a higher efficacy compared to 2-APB.
    KS0365 did not activate TRPV1, TRPV2 or TRPV4 channels. KS0365 triggered increases in [Ca2+ ]i, accelerated the EGF-induced keratinocyte migration in vitro.
    KS0365 induced strong Ca2+ responses in migrating front cells and in leading edges of keratinocytes.

    Physicochemical Properties

    M.Wt 250.766
    Formula C15H19ClO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-chloro-3-isopropylcyclopent-2-en-1-yl)-4-methylphenol

    References

    1. Marion Maier, et al. Br J Pharmacol. 2022 Aug 2. doi: 10.1111/bph.15937.

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