Triphenylphosphine oxide (TPPO)

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Chemical Structure : Triphenylphosphine oxide

CAS No.: 791-28-6

Catalog No.: PC-20366Not For Human Use, Lab Use Only.

Triphenylphosphine oxide (TPPO) is a selective and potent inhibitor of TRPM5 with IC50 of 12 and 30 uM for human and murine TRPM5 heterologously expressed in HEK293 cells.

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100 mg	$198	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Triphenylphosphine oxide (TPPO) is a selective and potent inhibitor of TRPM5 with IC50 of 12 and 30 uM for human and murine TRPM5 heterologously expressed in HEK293 cells.
TPPO displays no effect (up to 100 μM) on the membrane potential responses of TRPA1, TRPV1, or TRPM4b.
TPPO inhibited a calcium-gated TRPM5-dependent conductance in taste cells isolated from the tongues of transgenic TRPM5(+/)⁻ mice.

Physicochemical Properties

M.Wt	278.29
Formula	C18H15OP
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	triphenylphosphine oxide

References

1. Palmer RK, et al. Assay Drug Dev Technol. 2010 Dec;8(6):703-13.

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