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Chemical Structure : TRPM5 inhibitor NDNA
CAS No.: 936628-69-2
Catalog No.: PC-20367Not For Human Use, Lab Use Only.
TRPM5 inhibitor NDNA is potent and selecive TRPM5 inhibitor, inhibits Ca2+- induced TRPM5 currents with IC50 of 2.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $548 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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TRPM5 inhibitor NDNA is potent and selecive TRPM5 inhibitor, inhibits Ca2+- induced TRPM5 currents with IC50 of 2.4 nM.
NDNA binds to a region critical for channel gating, stabilizes the ion-conducting pore in an apo-like closed conformation.
NDNA inhibits Ca2+-induced TRPM5 activation in a non-competitive manner.
NDNA enhances insulin release, GLP-1 release, and insulin sensitivity.
TPPO dose-dependently inhibited acidic pHe-induced MMP-9 production in B16-BL6 cells (IC50=41 uM), but did not reduce cell viability.
NDNA (10 mg/kg. s.c.) significantly reduced spontaneous lung metastasis, without affecting tumor growth, body weight, or CBG, in tumor bearing mice.
| M.Wt | 348.40 | |
| Formula | C21H20N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N'-(3,4-dimethoxybenzylidene)-2-(naphthalen-1-yl)acetohydrazide |
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1. Ruan Z, et al. Nat Struct Mol Biol. 2021 Jul;28(7):604-613.
2. Bryant R et al. Patent WO2008097504. Use of a trpm5 inhibitor to regulate insulin and glp-1 release.
3. Toyonobu Maeda, et al. Oncotarget. 2017 Sep 11;8(45):78312-78326.
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