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Chemical Structure : AZ465
Catalog No.: PC-49702Not For Human Use, Lab Use Only.
AZ465 (AZ-465) is a potent selective TRPA1 inhibitor, potently inhibitor Zn2+ (100 μM)- and O-chlorobenzylidene malononitrile (CS) (10 nM)-induced TRPA1 activation with IC50 of 85 nM and 20 nM, respectively.
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AZ465 (AZ-465) is a potent selective TRPA1 inhibitor, potently inhibitor Zn2+ (100 μM)- and O-chlorobenzylidene malononitrile (CS) (10 nM)-induced TRPA1 activation with IC50 of 85 nM and 20 nM, respectively.
AZ465 displays a high degree of selectivity for TRPA1, with no effect on the responses of human TRPV1- and TRPM8-expressing cells to capsaicin or menthol, respectively.
AZ465 binds reversibly in the transmembrane region of human TRPA1.
AZ465 inhibits cinnamaldehyde-induced TRPA1 activation in hTRPA1 and mouse/human chimeric TRPA1 channels, but not in mTRPA1.
AZ465 (30 μM) reversibly inhibits cinnamaldehyde-activated TRPA1 currents in whole-cell patch-clamp experiments.
|AZ465 (10 and 50 μM) produced a significant inhibition of CS-evoked CGRP release in human dental pulp.
| M.Wt | 419.53 | |
| Formula | C24H29N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Eva Nyman, et al. J Pain Res. 2013;6:59-70. doi: 10.2147/JPR.S37567.
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