Catalog No.: PC-20552Not For Human Use, Lab Use Only.
GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels, also blocks cation-selective stretch-activated channels (SACs).
GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels, also blocks cation-selective stretch-activated channels (SACs).
GsMTx4 attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity.
GsMTx4 (5 μM) reduces Piezo1-mediated charge transfer to 38% of its initial levels in HEK293 cells transfected with Piezo1 cDNA.
GsMTx4 (5 μM) blocks cation-selective stretch-activated channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.
GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response.
GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice.
