TRPM5 agonist 39

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Chemical Structure : TRPM5 agonist 39

CAS No.:

Catalog No.: PC-49536Not For Human Use, Lab Use Only.

TRPM5 agonist 39 is a potent, selective transient receptor potential cation channel subfamily M member 5 (TRPM5) agonist with pEC50 of 7.1, shows high selectivity over TRPA1, TRPV1, TRPV4, TRPM4 and TRPM8.

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Purity & Documentation Purity: 99.1% (HPLC) Select Batch:

Biological Activity

TRPM5 agonist 39 is a potent, selective transient receptor potential cation channel subfamily M member 5 (TRPM5) agonist with pEC50 of 7.1, shows high selectivity over TRPA1, TRPV1, TRPV4, TRPM4 and TRPM8.

Physicochemical Properties

M.Wt	316.760
Formula	C17H14ClFN2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R, 3R)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile

References

1. M Sabat, et al. Bioorg Med Chem. 2022 Nov 6;76:117084.

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TRPM5 agonist 39

Biological Activity

Physicochemical Properties

References

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