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Chemical Structure : GRC-17536
Catalog No.: PC-49700Not For Human Use, Lab Use Only.
GRC-17536 (GRC 17536) is a potent and selective TRPA1 antagonist, inhibits citric acid -induced Ca+2 influx with IC50 of 8.2 nM in cell-based assays.
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GRC-17536 (GRC 17536) is a potent and selective TRPA1 antagonist, inhibits citric acid -induced Ca+2 influx with IC50 of 8.2 nM in cell-based assays.
GRC-17536 displays no significant activity against TRPV1, TRPV3, TRPV4, TRPM8 at 1 uM.
GRC 17536 (10 nM and 1 µM) inhibited LPS + AITC, Loxoribine + AITC and ssRNA40 + AITC induced 45Ca+2 uptake by 51.3% & 98.4%, 56.6% & 98.6% and 63.0% & 96.1% respectively in hTRPA1/CHO cells.
GRC 17536 blocked citric acid mediated cough in Guinea pigs, showed 79 and 89% inhibition of cough at 60 and 100 mg/kg respectively compared to the vehicle treated animal group.
| M.Wt | 516.46 | |
| Formula | C20H13F5N4O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mukhopadhyay I, et al. PLoS One. 2014 May 12;9(5):e97005.
2. Khairatkar J. N.et al. TRPA1 Antagonist for the Treatment of Pain Associated to Diabetic Neuropathic Pain. WO2016042501 A1, 2016.
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