Catalog No.: PC-49443Not For Human Use, Lab Use Only.
AMG21629 is a potent and selective TRPV1 antagonist, inhibits Ca2+ uptake by CHO cells expressing TRPV1 receptors with IC50 of 0.6 nM and 0.8 nM for capsaicin and acid-induced Ca2+ uptake, respectively.
AMG21629 is a potent and selective TRPV1 antagonist, inhibits Ca2+ uptake by CHO cells expressing TRPV1 receptors with IC50 of 0.6 nM and 0.8 nM for capsaicin and acid-induced Ca2+ uptake, respectively.
AMG21629 displayss >4000-fold selectivity for TRPV1 over other TRP channels.
AMG21629 blocks capsaicin-induced flinch response and causes hyperthermia in rats.
