WR1-002 (TRPML1 agonist C8)

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Chemical Structure : WR1-002

Catalog No.: PC-27704Not For Human Use, Lab Use Only.

WR1-002 (TRPML1 agonist C8) is a potent, selective agonist of lysosomal transient receptor potential mucolipin channel 1 (TRPML1), is >10x more potent than ML-SA1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

WR1-002 (TRPML1 agonist C8) is a potent, selective agonist of lysosomal transient receptor potential mucolipin channel 1 (TRPML1), is >10x more potent than ML-SA1.

Physicochemical Properties

M.Wt	553.06
Formula	C24H26ClFN4O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-[2-[4-(4-Chloro-2-fluorophenyl)-1-piperazinyl]phenyl]-N4,N4-dimethylbenzene-1,4-disulfonamide

References

1. Weiden EM, et al. EMBO J. 2026 Apr;45(7):2182-2209.

2. Patent WO2018/005713A1 (Compound 8).

3. Jonathan M Goodwin, et al. Sci Adv. 2021 Oct;7(40):eabj2485.

4. Kirsty M Hooper, et al. J Cell Biol. 2022 Jun 6;221(6):e202105112.

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