14-deoxy-11,12-didehydroandrographolide (DDA, DDHA)

Chemical Structure : 14-deoxy-11,12-didehydroandrographolide

CAS No.: 42895-58-9

Catalog No.: PC-28516Not For Human Use, Lab Use Only.

14-deoxy-11,12-didehydroandrographolide (DDA, DDHA) is an andrographolide metabolite within antiviral, antipyretic, immunostimulant and anticancer activities, potently inhibits cannabidiol (CBD)-evoked TRPV3 activation with IC50 of 7 nM, modulates the immune system by regulating chemokine signaling, Rap1 signaling, cytokine-cytokine receptor interaction, MAPK signaling, NF-kappa B signaling, RAS signaling, p53 signaling, HIF-1 signaling, and natural killer cell-mediated cytotoxicity.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$328	In stock
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Biological Activity

14-deoxy-11,12-didehydroandrographolide (DDA, DDHA) is an andrographolide metabolite within antiviral, antipyretic, immunostimulant and anticancer activities, potently inhibits cannabidiol (CBD)-evoked TRPV3 activation with IC50 of 7 nM, modulates the immune system by regulating chemokine signaling, Rap1 signaling, cytokine-cytokine receptor interaction, MAPK signaling, NF-kappa B signaling, RAS signaling, p53 signaling, HIF-1 signaling, and natural killer cell-mediated cytotoxicity.

Physicochemical Properties

M.Wt	332.44
Formula	C20H28O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	14-deoxy-11,12-didehydroandrographolide

References

1. Kumar RA, et al. J Ethnopharmacol. 2004 Jun;92(2-3):291-5.

2. Kalinovskii AP, et al. J Nat Prod. 2024 Jul 26;87(7):1852-1859.

3. Kalinovskii AP, et al. Cell Calcium. 2026 Oct 10;138:103201.

4. Khanal P, et al. RSC Adv. 2021 Jan 27;11(9):5065-5079.