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1-Azakenpaullone

Chemical Structure : 1-Azakenpaullone

CAS No.: 676596-65-9

1-Azakenpaullone (1-Akp)

Catalog No.: PC-63153Not For Human Use, Lab Use Only.

1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=2.0 and 4.2 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=2.0 and 4.2 uM).
1-Azakenpaullone stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells.

Physicochemical Properties

M.Wt 328.169
Formula C15H10BrN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

9-bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one

References

1. Kunick C, et al. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.

2. Mishra R, et al. J Biol Chem. 2007 Oct 19;282(42):30393-405.

3. Mfopou JK, et al. Stem Cell Res. 2014 Jan;12(1):166-77.

4. Liu H, et al. Diabetes. 2009 Mar;58(3):663-72.

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