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Chemical Structure : 1-Azakenpaullone
CAS No.: 676596-65-9
Catalog No.: PC-63153Not For Human Use, Lab Use Only.
1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=2.0 and 4.2 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $185 | In stock | |
| 25 mg | $385 | In stock | |
| 100 mg | $885 | In stock | |
| 1 g | Get quote |
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1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=2.0 and 4.2 uM); stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells.
| M.Wt | 328.169 | |
| Formula | C15H10BrN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
9-bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one |
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1. Kunick C, et al. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.
2. Mishra R, et al. J Biol Chem. 2007 Oct 19;282(42):30393-405.
3. Mfopou JK, et al. Stem Cell Res. 2014 Jan;12(1):166-77.
4. Liu H, et al. Diabetes. 2009 Mar;58(3):663-72.
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