| Cat. No. |
Product Name |
Information |
| PC-28134 |
ZDWX-25
DYRK1A/GSK3β inhibitor
|
ZDWX-25 is a potent dual DYRK1A/GSK3β inhibitor with IC50 of 103 nM and 71 nM for DYRK1A and GSK-3β respectively. |
| PC-28133 |
ZLWH-60
GSK3β inhibitor
|
ZLWH-60 is a potent GSK3β inhibitor with IC50 of 11.5 nM, inhibits phosphorylation of tau protein in Tau (P301L) 293 T cell, SH-SY5Y cell and HT22 cell. |
| PC-25363 |
KY19382
Wnt/beta-catenin agonist, CXXC5-Dvl inhibitor
|
KY19382 is a small molecule activator of Wnt/β-catenin signalling, effectively inhibits both GSK3β kinase activity and CXXC5-DVL interaction with IC50 of 10 nM and 19 nM respectively. |
| PC-20193 |
LY2090314
GSK-3 inhibitor
|
LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) with IC50 of 1.5/0.9 nM for GSK3α/GSK3β, respectively. |
| PC-20191 |
GSK3 inhibitor 117
GSK-3 inhibitor
|
GSK3 inhibitor 117 is a novel selective GSK-3 inhibitor, shows cytotoxicity against AML in vitro and in vivo. |
| PC-20114 |
GSK-3β inhibitor 47
GSK3β inhibitor
|
GSK-3β inhibitor 47 is a potent, selective, brain-penetrant, orally bioavailable GSK-3β inhibitor with IC50 of 0.73 nM, inhibits phosphorylated tau with cell IC50 of 58 nM. |
| PC-49290 |
Tideglusib
GSK-3 inhibitor
|
Tideglusib (NP031112, NP-12) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor with IC50 of 60 nM. |
| PC-49262 |
SB415286
GSK-3 inhibitor
|
SB-415286 (SB415286) is a potent, selective, ATP competitive small molecule inhibitor of GSK-3alpha with Ki of 31 nM, inhibits GSK-3beta with similar potency. |
| PC-38653 |
ARN25068
GSK-3β/FYN/DYRK1A inhibitor
|
ARN25068 is a highly potent, triple GSK-3β/FYN/DYRK1A inhibitor with IC50 of 4.17 and 2.17 μM for GSK-3β and FYN, reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. |
| PC-38527 |
GSK-3 Inhibitor XIII
GSK-3 inhibitor
|
GSK-3 Inhibitor XIII is a potent and ATP-binding site inhibitor of GSK-3. |
| PC-72725 |
COB-187
GSK-3 inhibitor
|
COB-187 (COB187) is a highly potent and selective inhibitor of GSK-3 with IC50 of 22/11 nM against GSK-3α/GSK-3β. |
| PC-63357 |
MMBO
GSK-3 inhibitor
|
MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively. |
