Catalog No.: PC-49262Not For Human Use, Lab Use Only.
SB-415286 (SB415286) is a potent, selective, ATP competitive small molecule inhibitor of GSK-3alpha with Ki of 31 nM, inhibits GSK-3beta with similar potency.
SB-415286 (SB415286) is a potent, selective, ATP competitive small molecule inhibitor of GSK-3alpha with Ki of 31 nM, inhibits GSK-3beta with similar potency.
SB-415286 stimulated glycogen synthesis in human liver cells and induced expression of a beta-catenin-LEF/TCF regulated reporter gene in HEK293 cells.
SB-415286 inhibited cellular GSK-3 activity as assessed by activation of glycogen synthase.
SB-415286 protected both central and peripheral nervous system neurones in culture from death induced by reduced PI 3-kinase pathway activity.
SB-415286 reduced the growth of AR-expressing prostate cancer cell lines.
