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Chemical Structure : SB415286
CAS No.: 264218-23-7
Catalog No.: PC-49262Not For Human Use, Lab Use Only.
SB-415286 (SB415286) is a potent, selective, ATP competitive small molecule inhibitor of GSK-3alpha with Ki of 31 nM, inhibits GSK-3beta with similar potency.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $248 | In stock | |
| 25 mg | $448 | In stock | |
| 100 mg | Get quote |
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SB-415286 (SB415286) is a potent, selective, ATP competitive small molecule inhibitor of GSK-3alpha with Ki of 31 nM, inhibits GSK-3beta with similar potency.
SB-415286 stimulated glycogen synthesis in human liver cells and induced expression of a beta-catenin-LEF/TCF regulated reporter gene in HEK293 cells.
SB-415286 inhibited cellular GSK-3 activity as assessed by activation of glycogen synthase.
SB-415286 protected both central and peripheral nervous system neurones in culture from death induced by reduced PI 3-kinase pathway activity.
SB-415286 reduced the growth of AR-expressing prostate cancer cell lines.
| M.Wt | 359.722 | |
| Formula | C16H10ClN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
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1. Coghlan MP, et al. Chem Biol. 2000 Oct;7(10):793-803.
2. Cross DA, et al. J Neurochem. 2001 Apr;77(1):94-102.
3. Mazor M, et al. Oncogene. 2004 Oct 14;23(47):7882-92.
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