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Chemical Structure : MMBO
Catalog No.: PC-63357Not For Human Use, Lab Use Only.
MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively.
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MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively; inhibits tau phosphorylation in primary neural cell culture and also in normal mouse brain, significantly decreases hippocampal tau phosphorylation at GSK-3 sites in transgenic mouse model of AD; suppresses tau pathology as assessed by AT8-immunoreactivity without affecting amyloid β pathology, significantly improves memory and cognitive deficits in AD models.
| M.Wt | 338.381 | |
| Formula | C18H14N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Onishi T, et al. J Neurochem. 2011 Dec;119(6):1330-40.
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