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MMBO

Chemical Structure : MMBO

CAS No.: 1005203-15-5

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MMBO (GSK-3 inhibitor MMBO)

Catalog No.: PC-63357Not For Human Use, Lab Use Only.

MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively.
    MMBO inhibits tau phosphorylation in primary neural cell culture and also in normal mouse brain, significantly decreases hippocampal tau phosphorylation at GSK-3 sites in transgenic mouse model of AD.
    MMBO suppresses tau pathology as assessed by AT8-immunoreactivity without affecting amyloid β pathology, significantly improves memory and cognitive deficits in AD models.

    Physicochemical Properties

    M.Wt 338.381
    Formula C18H14N2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole

    References

    1. Onishi T, et al. J Neurochem. 2011 Dec;119(6):1330-40.

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