| Cat. No. |
Product Name |
Information |
| PC-63312 |
BRD3731
GSK3β inhibitor
|
BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM). |
| PC-63311 |
BRD0705
GSK3α inhibitor
|
BRD0705 is a potent, paralog-selective GSK3α inhibitor with IC50 of 66 nM, 8-fold selectivity over GSK3β (IC50=515 nM). |
| PC-63239 |
Methyliodobikinin
GSK3-like kinase BIN2 inhibitor
|
Methyliodobikinin is a potent bikinin-like inhibitor targeting GSK3/Shaggy-like kinase, shows improved cell permeability, highly potent in vivo although it had lower activity in vitro. |
| PC-43377 |
CHIR-98014
GSK-3 inhibitor
|
CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively. |
| PC-43092 |
Bikinin
GSK3-like kinase BIN2 inhibitor
|
Bikinin (Abrasin) is a plant GSK-3/Shaggy-like kinases inhibitor that activates brassinosteroid (BR) signaling downstream of the BR receptor, binds and inhibits Arabidopsis thaliana GSK3-like kinases. |
| PC-42955 |
IM-12
GSK3β inhibitor
|
IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling. |
| PC-42827 |
SB216763
GSK-3 inhibitor
|
SB 216763 is a potent, selective, ATP competitive and cell permeable inhibitor GSK-3 with Ki of 9 nM (GSK-3α), equally potent for GSK-3β. |
| PC-63153 |
1-Azakenpaullone
GSK3β inhibitor
|
1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=2.0 and 4.2 uM). |
| PC-63152 |
Cazpaullone
GSK3β inhibitor
|
Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM). |
| PC-62878 |
BRD1172
GSK-3 inhibitor
|
BRD1172 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 3 nM/10 nM for GSK3α/GSK3β, respectively. |
| PC-62876 |
BRD0209
GSK3α/GSK3β inhibitor
|
BRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively. |
| PC-62530 |
ABC1183
GSK3/CDK9 inhibitor
|
ABC1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines. |
