Cat. No. |
Product Name |
Information |
PC-49262 |
SB415286
GSK-3 inhibitor
|
SB-415286 (SB415286) is a potent, selective, ATP competitive small molecule inhibitor of GSK-3alpha with Ki of 31 nM, inhibits GSK-3beta with similar potency. |
PC-38653 |
ARN25068
GSK-3β/FYN/DYRK1A inhibitor
|
ARN25068 is a highly potent, triple GSK-3β/FYN/DYRK1A inhibitor with sub-micromolar potency, reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. |
PC-38527 |
GSK-3 Inhibitor XIII
GSK-3 inhibitor
|
GSK-3 Inhibitor XIII is a potent and ATP-binding site inhibitor of GSK-3. |
PC-63357 |
MMBO
|
MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively. |
PC-63312 |
BRD3731
|
BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM). |
PC-63239 |
Methyliodobikinin
|
Methyliodobikinin is a potent bikinin-like inhibitor targeting GSK3/Shaggy-like kinase, shows improved cell permeability, highly potent in vivo although it had lower activity in vitro. |
PC-43377 |
CHIR-98014
|
CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively. |
PC-43092 |
Bikinin
|
Bikinin (Abrasin) is a plant GSK-3/Shaggy-like kinases inhibitor that activates brassinosteroid (BR) signaling downstream of the BR receptor, binds and inhibits Arabidopsis thaliana GSK3-like kinases. |
PC-42955 |
IM-12
|
IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling. |
PC-63152 |
Cazpaullone
|
Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM). |
PC-62878 |
BRD1172
|
BRD1172 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 3 nM/10 nM for GSK3α/GSK3β, respectively.. |
PC-62876 |
BRD0209
|
BRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively. |