Chemical Structure : BRD0209
Catalog No.: PC-62876Not For Human Use, Lab Use Only.
BRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively.
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BRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively; displays remarkable selectivity versus the kinome; causes a dramatic decrease in autophosphorylation at Tyr279 (pGSK3α) and Tyr216 (pGSK3β) with longer exposure (24h).
M.Wt | 347.462 | |
Formula | C22H25N3O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Wagner FF, et al. ACS Chem Biol. 2016 Jul 15;11(7):1952-63.
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