GSK3β-IN-1a (GSK-3β inhibitor 8) |CAS:1139875-74-3 Probechem Biochemicals

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Chemical Structure : GSK3β-IN-1a

CAS No.: 1139875-74-3

GSK3β-IN-1a (GSK-3β inhibitor 8)

Catalog No.: PC-62069Not For Human Use, Lab Use Only.

GSK3β-IN-1a (GSK-3β inhibitor 8) is a relatively selective and potent GSK-3β inhibitor with IC50 of 64 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK3β-IN-1a (GSK-3β inhibitor 8) is a relatively selective and potent GSK-3β inhibitor with IC50 of 64 nM.
GSK3β-IN-1a (GSK-3β inhibitor 8) induces replication of growth-arrested R7T1 β cells in a dose-dependent manner with EC50 of 1.1 uM, likely mediates β-cell proliferation through the Wnt signaling pathway.

Physicochemical Properties

M.Wt	413.924
Formula	C20H20ClN5OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

References

1. Wang W, et al. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32.

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GSK3β-IN-1a (GSK-3β inhibitor 8)

Biological Activity

Physicochemical Properties

References

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