IM-12 | GSK3β inhibitor | Probechem Biochemicals

Chemical Structure : IM-12

CAS No.: 1129669-05-1

IM-12 (GSK3β inhibitor IM-12, IM12)

Catalog No.: PC-42955Not For Human Use, Lab Use Only.

IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling.

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10 mg	$68	In stock
25 mg	$118	In stock
50 mg	$198	In stock
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Biological Activity

IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling.
IM-12 attenuates cell proliferation of ReNcell VM cells, induces nuclear accumulation of beta-catenin.

Physicochemical Properties

M.Wt	377.4115
Formula	C22H20FN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 54.9 mg/mL
Chemical Name/SMILES	1H-Pyrrole-2,5-dione, 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-

References

1. Schmöle AC, et al. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.

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IM-12 (GSK3β inhibitor IM-12, IM12)

Biological Activity

Physicochemical Properties

References

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