Elraglusib (9-ING-41) | GSK-3β inhibitor

Chemical Structure : 9-ING-41

CAS No.: 1034895-42-5

9-ING-41 (Elraglusib, 9ING41, 9-ING 41)

Catalog No.: PC-60431Not For Human Use, Lab Use Only.

Elraglusib (9-ING-41) is a novel potent, selective GSK-3β inhibitor with IC50 of 0.7 uM.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
50 mg	$428	In stock
100 mg		Get quote

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Biological Activity

Elraglusib (9-ING-41) is a novel potent, selective GSK-3β inhibitor with IC50 of 0.7 uM.
9-ING-41 demonstrates good antiproliferative activity against a panel of pancreatic cancer cell lines (IC50=0.5-5 uM), decreases XIAP expression and significantly induces apoptosis.
9-ING-41 affects energy homeostasis and induces autophagy, demonstrates tumor growth inhibition in vivo.

Physicochemical Properties

M.Wt	404.35
Formula	C22H13FN2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione

References

1. Gaisina IN, et al. J Med Chem. 2009 Apr 9;52(7):1853-63.

2. Pal K, et al. Mol Cancer Ther. 2014 Feb;13(2):285-96.

3. Ugolkov A, et al. Cancer Lett. 2016 Oct 1;380(2):384-92.

4. Hilliard TS, et al. Anticancer Drugs. 2011 Nov;22(10):978-85.

9-ING-41 (Elraglusib, 9ING41, 9-ING 41)

Biological Activity

Physicochemical Properties

References

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