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Cazpaullone

Chemical Structure : Cazpaullone

CAS No.: 914088-64-5

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Cazpaullone (9-Cyano-1-azapaullone)

Catalog No.: PC-63152Not For Human Use, Lab Use Only.

Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM).
    Cazpaullone stimulates INS-1E beta cell replication and protects INS-1E cells against glucolipotoxicity induced cell death.
    Cazpaullone also stimulates the replication of primary beta cells in isolated rat islets.

    Physicochemical Properties

    M.Wt 274.283
    Formula C16H10N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-Oxo-5,6,7,12-tetrahydropyrido(3',2'-2,3)azepino(4,5-b)indole-9-carbonitrile

    References

    1. Stukenbrock H, et al. J Med Chem. 2008 Apr 10;51(7):2196-207.

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