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Chemical Structure : Cazpaullone
Catalog No.: PC-63152Not For Human Use, Lab Use Only.
Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM).
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Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM).
Cazpaullone stimulates INS-1E beta cell replication and protects INS-1E cells against glucolipotoxicity induced cell death.
Cazpaullone also stimulates the replication of primary beta cells in isolated rat islets.
| M.Wt | 274.283 | |
| Formula | C16H10N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stukenbrock H, et al. J Med Chem. 2008 Apr 10;51(7):2196-207.
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