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Bikinin

Chemical Structure : Bikinin

CAS No.: 188011-69-0

Bikinin (Abrasin)

Catalog No.: PC-43092Not For Human Use, Lab Use Only.

Bikinin (Abrasin) is a plant GSK-3/Shaggy-like kinases inhibitor that activates brassinosteroid (BR) signaling downstream of the BR receptor, binds and inhibits Arabidopsis thaliana GSK3-like kinases.

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Biological Activity

Bikinin (Abrasin) is a plant GSK-3/Shaggy-like kinases inhibitor that activates brassinosteroid (BR) signaling downstream of the BR receptor, binds and inhibits Arabidopsis thaliana GSK3-like kinases; interferes directly with BIN2 kinase activity, also strongly inhibited the activity of the group I Arabidopsis GSK3 subfamilies, but not the ASKβ, ASKδ, and other Arabidopsis Ser/Thr kinases (AtMPK4, AtMPK6, and AtAURORA1); inhibits the SnRK2.3 kinase activity and its T180 phosphorylation in vivo.

Physicochemical Properties

M.Wt 273.0834
Formula C9H9BrN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 42 mg/mL

Chemical Name/SMILES

Butanoic acid, 4-[(5-bromo-2-pyridinyl)amino]-4-oxo-

References

1. De Rybel B, et al. Chem Biol. 2009 Jun 26;16(6):594-604.

2. Cai Z, et al. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9651-6.

3. Rozhon W, et al. BMC Plant Biol. 2014 Jun 19;14:172.

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