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Bikinin

Chemical Structure : Bikinin

CAS No.: 188011-69-0

Bikinin (Abrasin)

Catalog No.: PC-43092Not For Human Use, Lab Use Only.

Bikinin (Abrasin) is a plant GSK-3/Shaggy-like kinases inhibitor that activates brassinosteroid (BR) signaling downstream of the BR receptor, binds and inhibits Arabidopsis thaliana GSK3-like kinases.

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Biological Activity

Bikinin (Abrasin) is a plant GSK-3/Shaggy-like kinases inhibitor that activates brassinosteroid (BR) signaling downstream of the BR receptor, binds and inhibits Arabidopsis thaliana GSK3-like kinases.
Bikinin interferes directly with BIN2 kinase activity, also strongly inhibited the activity of the group I Arabidopsis GSK3 subfamilies, but not the ASKβ, ASKδ, and other Arabidopsis Ser/Thr kinases (AtMPK4, AtMPK6, and AtAURORA1).
Bikinin inhibits the SnRK2.3 kinase activity and its T180 phosphorylation in vivo.

Physicochemical Properties

M.Wt 273.0834
Formula C9H9BrN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 42 mg/mL

Chemical Name/SMILES

Butanoic acid, 4-[(5-bromo-2-pyridinyl)amino]-4-oxo-

References

1. De Rybel B, et al. Chem Biol. 2009 Jun 26;16(6):594-604.

2. Cai Z, et al. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9651-6.

3. Rozhon W, et al. BMC Plant Biol. 2014 Jun 19;14:172.

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