Tideglusib (NP031112, NP-12) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor with IC50 of 60 nM.
Tideglusib (NP031112) is a potent anti-inflammatory and neuroprotective agent against KA-induced in vivo excitotoxicity.
Tideglusib (NP031112) inhibits glutamate-induced glial activation and protects cortical neurons from cell death in vitro.
Tideglusib (NP031112) attenuates glutamate-induced excitotoxic glial activation and neuronal damage.
