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Chemical Structure : LY2090314
CAS No.: 603288-22-8
Catalog No.: PC-20193Not For Human Use, Lab Use Only.
LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) with IC50 of 1.5/0.9 nM for GSK3α/GSK3β, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | $928 | In stock | |
| 1 g | Get quote |
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LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) with IC50 of 1.5/0.9 nM for GSK3α/GSK3β, respectively.
LY2090314 stimulated TCF/LEF TOPFlash reporter activity, stabilized β-catenin and elevated the expression of Axin2 in a panel of melanoma cell lines at nM potency.
LY2090314 exhibited cytotoxicity against melanoma cell lines in vitro with IC50 of 10 nM, but not other solid tumor cell lines (IC50 >10 uM).
LY2090314 elevates Axin2 gene expression after a single dose and produces tumor growth delay in A375 melanoma xenografts with repeat dosing.
| M.Wt | 512.55 | |
| Formula | C28H25FN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[9-fluoro-2-(piperidin-1-ylcarbonyl)-1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-1H-pyrrole-2,5-dione |
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1. Atkinson JM, et al. PLoS One. 2015 Apr 27;10(4):e0125028.
2. Rizzieri DA, et al. Leuk Lymphoma. 2016 Aug;57(8):1800-6.
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