1-Piperidine Propionic Acid | PAR2 inhibitor

Chemical Structure : 1-Piperidine Propionic Acid

CAS No.: 26371-07-3

1-Piperidine Propionic Acid (1-PPA)

Catalog No.: PC-21762Not For Human Use, Lab Use Only.

1-Piperidine Propionic Acid (1-PPA) is an allosteric Inhibitor of protease activated receptor-2 (PAR2) with IC50 of 2.3 uM.

Packing	Price	Stock
10 mg	$128	In stock
25 mg	$198	In stock
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Biological Activity

1-Piperidine Propionic Acid (1-PPA) is an allosteric Inhibitor of protease activated receptor-2 (PAR2) with IC50 of 2.3 uM.
1-PPA binds PAR2 in an allosteric pocket of the receptor inactive conformation.
1-PPA reduces platelet aggregation, inhibits the PAR2-C/EBP-β-SerpinB3 axis and protects from NASH development and progression.

Physicochemical Properties

M.Wt	157.21
Formula	C8H15NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(piperidin-1-yl)propanoic acid

References

1. Villano Gianmarco, et al. Mol Metab. 2024 Feb 1:81:101889.

2. Chinellato M, et al. Pharmaceuticals (Basel). 2023 Oct 18;16(10):1486.

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1-Piperidine Propionic Acid (1-PPA)

Biological Activity

Physicochemical Properties

References

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