| Cat. No. |
Product Name |
Information |
| PC-49647 |
PAR1 inhibitor Q94
PAR1 antagonist
|
Q94 is a selective PAR1 antagonist and allosteric modulator that selectively block PAR(1) /Gα(q) interaction and signalling. |
| PC-73008 |
UDM-001651
PAR4 inhibitor
|
UDM-001651 (UDM001651) is a potent, selective, and orally bioavailable PAR4 antagonist with IC50 of 2.4 nM. |
| PC-72283 |
PAR2 antagonist C391
PAR2 antagonist
|
PAR2 antagonist C391 (C391) is a selective PAR2 antagonist, potently inhibits peptidomimetic-induced PAR2 Ca2+ signalling with IC50 of 1.3 uM. |
| PC-38310 |
I-287
PAR2 inhibitor
|
I-287 is a potent, selective, orally active inhibitor of PAR2, negative PAR2 allosteric modulator, inhibits PAR2-mediated activation of Gq and G12/13 but not Gi/o proteins (IC50=45-390 nM). |
| PC-60320A |
AZ8838 racemate
PAR2 inhibitor
|
AZ8838 racemate (AZ-8838 racemate) is the racemate form of AZ8838, which is a potent, and selective PAR2 antagonist with Kd of 125 nM.. |
| PC-35139 |
BAY-386
PAR1 antagonist
|
BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM). |
| PC-62640 |
Parmodulin 2
PAR-1 antagonist
|
Parmodulin 2 (ML161) is a potent, specific antagonist of PAR-1, specifically inhibits thrombin-tethered ligand (TL) peptide-mediated platelet aggregation with IC50 of 7 uM. |
| PC-62125 |
ML354
PAR4 antagonist
|
ML354 (VU0099704) is a novel potent and selective PAR4 antagonist with IC50 of 140 nM, displays 71-fold selectivity versus PAR-1. |
| PC-62088 |
I-191
PAR2 inhibitor
|
I-191 (I191, I 191) is a novel potent, selective protease-activated receptor 2 (PAR2) antagonist with pIC50 of 7.2 in cell-based assays. |
| PC-62040 |
JF-5
PAR1 antagonist
|
JF5 (PAR1 inhibitor JF5) is an allosteric inhibitor of PAR1 that binds to helix 8 of the receptor. |
| PC-61618 |
GB-83
PAR2 inhibitor
|
GB-83 is a selective, reversible PAR2 (Protease-activated receptor 2) antagonist with IC50 of 2 uM. |
| PC-61561 |
ENMD-1068
PAR2 inhibitor
|
ENMD-1068 is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling. |
