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Chemical Structure : PAR1 inhibitor Q94
Catalog No.: PC-49647Not For Human Use, Lab Use Only.
Q94 is a selective PAR1 antagonist and allosteric modulator that selectively block PAR(1) /Gα(q) interaction and signalling.
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Q94 is a selective PAR1 antagonist and allosteric modulator that selectively block PAR(1) /Gα(q) interaction and signalling.
Q94 caused an approximately fourfold decrease in thrombin EC50 value, did not alter the Ca(2+) response mediated by a PAR(2) activating peptide.
Q94 suppressed the doxorubicin-induced increase in activities of caspase-9 and caspase-3 in podocytes.
Q94 treatment significantly attenuated periodic acid-Schiff and desmin staining, indicators of podocyte injury, and also decreased glomerular levels of podocin and nephrin in mouse model of nephropathy.
| M.Wt | 369.29 | |
| Formula | C21H18Cl2N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Asteriti S, et al. Br J Pharmacol. 2012 Sep;167(1):80-94.
2. Guan Y, et al. J Pharmacol Sci. 2017 Sep 14:S1347-8613(17)30128-7.
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