PAR4 Agonist Peptide AYPGKF-NH2 | PAR4 agonist

Chemical Structure : PAR4 Agonist Peptide AYPGKF-NH2

CAS No.: 352017-71-1

PAR4 Agonist Peptide AYPGKF-NH2 (PAR4-AP)

Catalog No.: PC-20579Not For Human Use, Lab Use Only.

PAR4 Agonist Peptide AYPGKF-NH2 (PAR4-AP) is a potent, PAR4-selective agonist peptide, stimulates platelet aggregation in vitro with EC50 of 15 uM, shows no significant interaction with either PAR1 or PAR2.

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Biological Activity

PAR4 Agonist Peptide AYPGKF-NH2 (PAR4-AP) is a potent, PAR4-selective agonist peptide, stimulates platelet aggregation in vitro with EC50 of 15 uM, shows no significant interaction with either PAR1 or PAR2.

AYPGKF activates and desensitizes PAR4 in platelets and, like thrombin, triggers phosphoinositide hydrolysis but not inhibition of adenylyl cyclase in PAR4-expressing cells.

AYPGKF is more potent than the native GYPGKF sequence at stimulating PAR4-mediated phosphoinositide hydrolysis.

AYPGKF effectively desensitizes PAR4-mediated signaling in human platelets.

Physicochemical Properties

M.Wt	680.81
Formula	C34H48N8O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ala-Tyr-Pro-Gly-Lys-Phe-NH2

References

1. T R Faruqi, et al. J Biol Chem. 2000 Jun 30;275(26):19728-34. 2. Zhikang Xu, et al. Cell Rep. 2026 Jun 30;45(7):117632.

PAR4 Agonist Peptide AYPGKF-NH2 (PAR4-AP)

Biological Activity

Physicochemical Properties

References

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