Catalog No.: PC-25413Not For Human Use, Lab Use Only.
E6795 (E-6795) is a potent, selective and orally available protease-activated receptor 2 (PAR-2) inhibitor with IC50 of 6.56 nM in cell-based calcium influx assays.
E6795 (E-6795) is a potent, selective and orally available protease-activated receptor 2 (PAR-2) inhibitor with IC50 of 6.56 nM in cell-based calcium influx assays.
E6795 does not inhibit thrombin-induced PAR-1 activity, also exhibits high selectivity for PAR-2 over broad kinase and pharmacological panels.
E6795 suppresses inflammation and immune cell infiltration in the MC903-induced AD mouse model
E6795 not only attenuates dermatitis and reduces dermal inflammatory cell infiltration but also improves epidermal barrier function directly or indirectly in the MC903 mouse model.
Topical 2 % E6795 cream reduces inflammation, epidermal thickening, and pruritus in Nc/Nga mice.
