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Chemical Structure : PAR2 antagonist C391
Catalog No.: PC-72283Not For Human Use, Lab Use Only.
PAR2 antagonist C391 (C391) is a selective PAR2 antagonist, potently inhibits peptidomimetic-induced PAR2 Ca2+ signalling with IC50 of 1.3 uM.
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PAR2 antagonist C391 (C391) is a selective PAR2 antagonist, potently inhibits peptidomimetic-induced PAR2 Ca2+ signalling with IC50 of 1.3 uM.
C391 blocks both PAR2 Ca2+ and MAPK signalling pathways activated by peptidomimetics and/or proteinase activation.
C391 effectively attenuated compound 48/80-induced thermal hyperalgesia in vivo.
C391 blocked A. alternata-induced, PAR2-dependent Ca2+ and MAPK signalling in 16HBE14o- cells, as well as β-arrestin recruitment in HEK 293 cells.
C391 effectively attenuated A. alternata-induced inflammation, mucus production, mucus cell hyperplasia and airway hyperresponsiveness in acute allergen-challenged murine models.
| M.Wt | 767.88 | |
| Formula | C38H53N7O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Candy M Rivas, et al. Br J Pharmacol. 2021 Nov 28. doi: 10.1111/bph.15745.
2. Scott Boitano, et al. Br J Pharmacol. 2015 Sep;172(18):4535-4545.
3. Hassler SN, et al. Cephalalgia. 2019 Jan;39(1):111-122.
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