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Chemical Structure : BMS-986141
Catalog No.: PC-20965Not For Human Use, Lab Use Only.
BMS-986141 is a potent, selective antagonist of protease-activated receptor 4 (PAR4) with IC50 of 0.4 nM, Kd of 0.1 nM.
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BMS-986141 is a potent, selective antagonist of protease-activated receptor 4 (PAR4) with IC50 of 0.4 nM, Kd of 0.1 nM.
BMS-986141 potently inhibits platelet aggregation induced with a PAR4 agonist peptide (25 μM) with IC50 of 2.2 nM.
BMS-986141 shows no effect on platelet aggregation induced by a PAR1 antagonist peptide, adenosine diphosphate, collagen, or the thromboxane A2 receptor agonist U46619 up to 1 uM.
BMS-986141 (0.5 and 1 mg/kg) demonstrated excellent antithrombotic efficacy and minimal bleeding time prolongation in monkey models relative to the clinically important antiplatelet agent clopidogrel.
| M.Wt | 561.63 | |
| Formula | C27H23N5O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. E Scott Priestley, et al. J Med Chem. 2022 Jul 14;65(13):8843-8854.
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