| Cat. No. |
Product Name |
Information |
| PC-60320 |
AZ-8838
PAR2 inhibitor
|
AZ-8838 (AZ8838) is a potent, and selective PAR2 antagonist with Kd of 125 nM. |
| PC-60319 |
GB-110
PAR2 agonist
|
GB-110 is a potent, non-peptidic agonist of PAR2 that selectively induces PAR2-mediated intracellular Ca(2+) release in HT29 cells with EC50 of 0.28 uM. |
| PC-60318 |
GB-88
PAR2 inhibitor
|
GB-88 is a selective, orally available PAR2 antagonist that inhibits PAR2 activated Ca(2+) release with IC50 of 2 uM. |
| PC-42330 |
Vorapaxar
PAR1 antagonist
|
Vorapaxar (SCH 530348) is a potent, selective and orally active thrombin receptor PAR-1 antagonist with Ki of 8.1 nM. |
| PC-47484 |
TRAP-6
PAR1 agonist
|
TRAP-6 is a PAR1 peptide fragment (residues 42-47) that acts as a protease activating receptor 1 (PAR1) agonist, stimulates platelet aggregation (EC50=0.8 uM). |
| PC-21812 |
PAR4 antagonist 48
PAR4 antagonist
|
PAR4 antagonist 48 is a potent and selective quinoxaline-based PAR4 antagonist with IC50 of 1.8 nM in FLIPR calcium mobilization assays, inhibits calcium mobilization in human platelet-rich plasma (PRP) aggregation assay with γ-thrombin with IC50 of 2.1 nM. |
| PC-21762 |
1-Piperidine Propionic Acid
PAR2 inhibitor
|
1-Piperidine Propionic Acid (1-PPA) is an allosteric Inhibitor of protease activated receptor-2 (PAR2) with IC50 of 2.3 uM. |
| PC-20882 |
PAR2 antagonist C781
PAR2 antagonist
|
PAR2 antagonist C781 is a potent β-Arrestin biased protease-activated receptor-2 (PAR2) antagonist, effectively reduces 2AT, trypsin and elastase-induced signalling in vitro physiological assays. |
| PC-20579 |
AYPGKF-NH2
PAR4 agonist
|
AYPGKF-NH2 is a potent, PAR4-selective agonist peptide, stimulates platelet aggregation in vitro with EC50 of 15 uM. |
| PC-20578 |
TFLLRN-NH2
PAR1 agonist
|
TFLLRN-NH2 is a potent, PAR1-selective agonist peptide with EC50 of 1.9 uM. |
| PC-20577 |
RWJ-58259
PAR1 antagonist
|
RWJ-58259 (RWJ58259) is a potent, selective thrombin receptor PAR-1 antagonist with binding IC50 of 0.15 uM, and IC50 of 0.07 uM in RASMC calcium mobilization assays. |
