Catalog No.: PC-27324Not For Human Use, Lab Use Only.
PAR4 Agonist Peptide AYPGKF-NH2 TFA (PAR4-AP) is a potent, PAR4-selective agonist peptide, stimulates platelet aggregation in vitro with EC50 of 15 uM, shows no significant interaction with either PAR1 or PAR2.
PAR4 Agonist Peptide AYPGKF-NH2 TFA (PAR4-AP) is a potent, PAR4-selective agonist peptide, stimulates platelet aggregation in vitro with EC50 of 15 uM, shows no significant interaction with either PAR1 or PAR2. AYPGKF activates and desensitizes PAR4 in platelets and, like thrombin, triggers phosphoinositide hydrolysis but not inhibition of adenylyl cyclase in PAR4-expressing cells. AYPGKF is more potent than the native GYPGKF sequence at stimulating PAR4-mediated phosphoinositide hydrolysis. AYPGKF effectively desensitizes PAR4-mediated signaling in human platelets.
Physicochemical Properties
M.Wt
680.81
Formula
C34H48N8O7
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Ala-Tyr-Pro-Gly-Lys-Phe-NH2
References
1. Zhikang Xu, et al. Cell Rep. 2026 Jun 30;45(7):117632.
