Chemical Structure : RWJ-56110
CAS No.:
252889-88-6
RWJ-56110
(RWJ56110)
Catalog No. : PC-61304Not For Human Use, Lab Use Only.
RWJ-56110 is a potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6130401
Biological Activity
RWJ-56110 is a potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4.
Physicochemical Properties
M.Wt
863.65
Formula
C41H43Cl2F2N7O3.2HC
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(αS)-N-[(1S)-3-Amino-1-[[(phenylmethyl)amino]carbonyl]propyl]-α-[[[[1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indol-6-yl]amino]carbonyl]amino]-3,4-difluoro-benzenepropanamide
References
1. Andrade-Gordon P, et al. Proc Natl Acad Sci U S A.
2. Zhang HC, et al. Bioorg Med Chem Lett.
3. Tanaka M, et al. J Pharmacol Sci.
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