Chemical Structure : GB-88
CAS No.:
1416435-96-5
GB-88
(PAR2 antagonist, GB88)
Catalog No. : PC-60318Not For Human Use, Lab Use Only.
GB-88 is a selective, orally available PAR2 antagonist that inhibits PAR2 activated Ca(2+) release with IC50 of 2 uM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6031801
Biological Activity
GB-88 is a selective, orally available PAR2 antagonist that inhibits PAR2 activated Ca(2+) release with IC50 of 2 uM.
Physicochemical Properties
M.Wt
546.712
Formula
C32H42N4O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-((S)-3-cyclohexyl-1-(((2S,3S)-3-methyl-1-oxo-1-(spiro[indene-1,4'-piperidin]-1'-yl)pentan-2-yl)amino)-1-oxopropan-2-yl)isoxazole-5-carboxamide
References
1. Suen JY, et al. Br J Pharmacol.
2. Lohman RJ, et al. J Pharmacol Exp Ther.
3. Cheng RKY, et al. Nature.
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