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Chemical Structure : GB-88
CAS No.: 1416435-96-5
Catalog No.: PC-60318Not For Human Use, Lab Use Only.
GB-88 is a selective, orally available PAR2 antagonist that inhibits PAR2 activated Ca(2+) release with IC50 of 2 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GB-88 is a selective, orally available PAR2 antagonist that inhibits PAR2 activated Ca(2+) release with IC50 of 2 uM.
GB-88 (10 mg/kg) inhibits acute colonic inflammation induced in rats by the PAR2 agonist SLIGRL-NH2 with markedly reduced edema, mucin depletion, PAR2 receptor internalization, and mastocytosis.
| M.Wt | 546.712 | |
| Formula | C32H42N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((S)-3-cyclohexyl-1-(((2S,3S)-3-methyl-1-oxo-1-(spiro[indene-1,4'-piperidin]-1'-yl)pentan-2-yl)amino)-1-oxopropan-2-yl)isoxazole-5-carboxamide |
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1. Suen JY, et al. Br J Pharmacol. 2012 Mar;165(5):1413-23.
2. Lohman RJ, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):256-65.
3. Cheng RKY, et al. Nature. 2017 May 4;545(7652):112-115.
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