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GB-110

Chemical Structure : GB-110

CAS No.: 1252806-70-4

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GB-110 (GB 110;GB110)

Catalog No.: PC-60319Not For Human Use, Lab Use Only.

GB-110 is a potent, non-peptidic agonist of PAR2 that selectively induces PAR2-mediated intracellular Ca(2+) release in HT29 cells with EC50 of 0.28 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GB-110 is a potent, non-peptidic agonist of PAR2 that selectively induces PAR2-mediated intracellular Ca(2+) release in HT29 cells with EC50 of 0.28 uM.
GB-110 displays no activity for PAR-1 receptors.

Physicochemical Properties

M.Wt 608.784
Formula C33H48N6O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((S)-1-(((2S,3S)-1-((3-(4-(aminomethyl)piperidine-1-carbonyl)benzyl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-cyclohexyl-1-oxopropan-2-yl)isoxazole-5-carboxamide

References

1. Barry GD, et al. J Med Chem. 2010 Oct 28;53(20):7428-40.

2. Suen JY, et al. Br J Pharmacol. 2012 Mar;165(5):1413-23.

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