AC-264613 |CAS:1051487-82-1 Probechem Biochemicals

Chemical Structure : AC-264613

AC-264613 (AC 264613;AC264613)

Catalog No.: PC-60662Not For Human Use, Lab Use Only.

AC-264613 is a novel potent, selective protease-activated receptor PAR2 agonist with potencies ranging from 30-100 nM.

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Biological Activity

AC-264613 is a novel potent, selective protease-activated receptor PAR2 agonist with potencies ranging from 30-100 nM.
AC-264613 shows no activity at other PAR receptor subtypes and 30 other targets involved in nociception.
AC-264613 elicits robust and persistent thermal hyperalgesia and edema in vivo.
AC-264613 also decreases IRF5 expression and also significantly reduces p53 protein expression in macrophages.

Physicochemical Properties

M.Wt	400.276
Formula	C19H18BrN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-oxo-4-phenylpyrrolidine-3-carboxylic acid [1-(3-bromo-phenyl)-(E/Z)-ethylidene]-hydrazide

References

1. Ma JN, et al. J Pharmacol Exp Ther. 2013 Dec;347(3):697-704.

2. Gardell LR, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):799-808.

3. Yamaguchi R, et al. Cell Biol Int. 2016 Jun;40(6):629-41.

AC-264613 (AC 264613;AC264613)

Biological Activity

Physicochemical Properties

References

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