SCH79797 dihydrochloride is a potent, selective competitive and nonpeptide PAR-1 antagonist with IC50 of 70 nM.
SCH79797 inhibits α-thrombin- and haTRAP-induced aggregation of human platelets, but does inhibits human platelet aggregation induced by the tethered ligand agonist for PAR-4, γ-thrombin, ADP, or collagen.
SCH79797 also blocks angiogenesis association with endothelial cell growth suppression and induction of apoptosis.
