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Chemical Structure : Vorapaxar
CAS No.: 618385-01-6
Catalog No.: PC-42330Not For Human Use, Lab Use Only.
Vorapaxar (SCH 530348) is a potent, selective and orally active thrombin receptor PAR-1 antagonist with Ki of 8.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | Get quote |
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Vorapaxar (SCH 530348) is a potent, selective and orally active thrombin receptor PAR-1 antagonist with Ki of 8.1 nM.
Vorapaxar (SCH 530348) displays no activity against e PAR-2, PAR-3 and PAR-4, and no CYP450 enzyme inhibition potential.
Vorapaxar (SCH 530348) inhibits thrombin (10 nM) induced human platelet aggregation with IC50 of 47 nM.
Vorapaxar (SCH 530348) inhibits haTRAP-induced platelet aggregation in vivo.
| M.Wt | 492.5817 | |
| Formula | C29H33FN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester |
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1. Chackalamannil S, et al. J Med Chem. 2008 Jun 12;51(11):3061-4.
2. Chintala M, et al. J Pharmacol Sci. 2008 Dec;108(4):433-8.
3. Goto S, et al. J Atheroscler Thromb. 2010 Feb 26;17(2):156-64.
4. Becker RC, et al. Lancet. 2009 Mar 14;373(9667):919-28.
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