BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.
BMS-986120 selectivity inhibits PAR4 AP-induced cellular calcium mobilization in HEK cells with IC5o of 0.56 nM, with no activity on PAR1 and PAR2.
BMS-986120 inhibits human PRP aggregation in response to γ-thrombin in vitro with IC50 of 7.3 nM.
BMS-986120 demonstrates potent and highly efficacious antithrombotic activity with low bleeding in vivo.
