1.21S9N

Chemical Structure : 1.21S9N

Catalog No.: PC-26484Not For Human Use, Lab Use Only.

1.21S9N is a potent, dual HIF-1/2 inhibitor with MST Kd of 2.2 nM for HIF-1α, inhibits the interaction of HIF-1α and HIF-2α with HIF-1β with IC50 of 72 nM and 128 nM in immunoblot assays.

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Biological Activity

1.21S9N is a potent, dual HIF-1/2 inhibitor with MST Kd of 2.2 nM for HIF-1α, inhibits the interaction of HIF-1α and HIF-2α with HIF-1β with IC50 of 72 nM and 128 nM in immunoblot assays.
1.21S9N (40 mg/kg BID) showed superior activity against breast and colorectal cancer models compared within PT2385, inhibited hypoxia-induced adrenomedullin (Adm) mRNA expression.

Physicochemical Properties

M.Wt	510.76
Formula	C27H38N6S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-(propane-1,3-diyl)bis(N-(pyridine-4-ylmethyl)piperidine-1-carbothioamide)

References

1. Salman S, et al. J Exp Med. 2026 May 4;223(5):e20251009.

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1.21S9N

Biological Activity

Physicochemical Properties

References

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