| Cat. No. |
Product Name |
Information |
| PC-20456 |
ER-400583-00
HIF-1α inhibitor
|
ER-400583-00 is a small-molecule HIF-1α inhibitor, inhibits the induction of HIF-1 reporter activity in response to hypoxia with IC50 of 7.9 nM. |
| PC-20172 |
BAY 87-2243
HIF-1 inhibitor
|
BAY 87-2243 (BAY87-2243) is a highly potent, selective inhibitor of hypoxia-induced gene activation (IC50=0.7 nM), directly inhibits mitochondrial complex I. |
| PC-49374 |
ISCA2 inhibitor 25
ISCA2 inhibitor
|
ISCA2 inhibitor 25 is a selective, orally available small molecule inhibitor of HIF-2α with IC50 of 0.92 uM, decrease HIF-1/2α levels and induce ferroptosis by targeting Iron Sulfur Cluster Assembly 2 (ISCA2), a component of the late mitochondrial Iron Sulfur Cluster (L-ISC) assembly complex. |
| PC-72737 |
Belzutifan
HIF2α inhibitor
|
Belzutifan (PT2977, MK-6482) is a potent and selective small-molecule inhibitor of HIF2α with SPA IC50 of 9 nM, EC50 of 11 nM (HIF-2α luciferase assay). |
| PC-72705 |
KUSC-5037
HIF-1 inhibitor
|
KUSC-5037 (KUSC5037) is a novel effective HIF-1 inhibitor with IC50 of 1.2 uM against HIF-1 transcriptional activity. |
| PC-72532 |
YQ-0629
HIF-2α inhibitor
|
YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM. |
| PC-72330 |
HIF inhibitor 208
HIF inhibitor
|
HIF inhibitor 208 is a small molecule inhibitor of HIF pathway with IC50 of 0.5 nM. |
| PC-72329 |
Arylsulfonamide 64B
HIF inhibitor
|
Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule inhibitor of HIF pathway, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration. |
| PC-38083 |
Izilendustat
HIF-PHD inhibitor
|
Izilendustat is a potent inhibitor of HIF prolyl hydroxylase (PHD) which stabilizes hypoxia inducible factor- 1 alpha (HIF- lα), as well as hypoxia inducible factor-2 (HIF-2).. |
| PC-38033 |
HIF-2α-IN-2
HIF-2α inhibitor
|
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor with IC50 of 16 nM in scintillation proximity assay, extracted from patent WO2015035223A1, Compound 232. |
| PC-35912 |
KCN1
HIF-1 inhibitor
|
KCN1 (HIF inhibitor KCN1) is a small molecule inhibitor of the HIF-1 pathway, antagonizes HIF transcription in bioassay, blocks the p300/HIF-1α interaction, and exert potent anticancer activity in vitro and in vivo. |
| PC-43531 |
Roxadustat
HIF-PHD inhibitor
|
Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM. |
