| Cat. No. |
Product Name |
Information |
| PC-62483 |
OHM1
HIF-1α inhibitor
|
OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells. |
| PC-62366 |
KG-548
ARNT/TACC3 inhibitor
|
KG-548 is an ARNT/TACC3 disruptor (IC50=25 uM) that selectively bind within the ARNT PAS (Per-ARNT-Sim) domain that recruits TACC3.. |
| PC-62044 |
KHS101
TACC3 inhibitor
|
KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM). |
| PC-61213 |
JNJ-42905343
HIF-PHD inhibitor
|
JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively. |
| PC-70269 |
HIF1-IN-2
HIF-1 inhibitor
|
HIF1-IN-2 is a potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB. |
| PC-60851 |
NOFD
FIH inhibitor
|
NOFD (N-oxalyl-d-phenylalanine) is a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM). |
| PC-60850 |
DM-NOFD
FIH inhibitor
|
DM-NOFD is the dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM). |
| PC-60509 |
Desidustat
HIF-PHD inhibitor
|
Desidustat (ZYAN1) is a novel HIF prolyl hydroxylase (PHD) inhibitor under clinical development for the treatment of anemia. |
| PC-60370 |
IDF-11774
HIF-1α inhibitor
|
IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells. |
| PC-60317 |
PT2399
HIF-2α inhibitor
|
PT2399 (PT 2399, PT-2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain. |
| PC-60308 |
MK-8617
HIF-PHD inhibitor
|
MK-8617 is a potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively. |
| PC-60148 |
JTZ-951 hydrochloride
HIF-PHD inhibitor
|
Enarodustat hydrochloride (JTZ-951 hydrochloride) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2. |
