| Cat. No. |
Product Name |
Information |
| PC-60850 |
DM-NOFD
FIH inhibitor
|
DM-NOFD is the dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM). |
| PC-60509 |
Desidustat
HIF-PHD inhibitor
|
Desidustat (ZYAN1) is a novel HIF prolyl hydroxylase (PHD) inhibitor under clinical development for the treatment of anemia. |
| PC-60370 |
IDF-11774
HIF-1α inhibitor
|
IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells. |
| PC-60317 |
PT2399
HIF-2α inhibitor
|
PT2399 (PT 2399, PT-2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain. |
| PC-60308 |
MK-8617
HIF-PHD inhibitor
|
MK-8617 is a potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively. |
| PC-60148 |
JTZ-951 hydrochloride
HIF-PHD inhibitor
|
Enarodustat hydrochloride (JTZ-951 hydrochloride) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2. |
| PC-60147 |
JTZ-951
HIF-PHD inhibitor
|
Enarodustat (JTZ-951) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2. |
| PC-45660 |
THS-044
HIF2α modulator
|
THS-044 is a low micromolar HIF2α PAS-B binding compound (Kd=2 uM). |
| PC-45555 |
KC7F2
HIF-1α inhibitor
|
KC7F2 is a small molecule HIF-1α translation inhibitor with IC50 of 20 uM. |
| PC-42474 |
PX-478
HIF-1α inhibitor
|
PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity. |
| PC-45759 |
HIF2α-IN-1
|
A potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay. . |
| PC-42346 |
Vadadustat
HIF-PHD inhibitor
|
Vadadustat (PG-1016548, AKB-6548) is a novel, potent, orally active HIF prolyl-4-hydroxylase (HIF-PHD) inhibitor with pKi of for PHD1, PHD2, and PHD3, respecitvely. |
