| Cat. No. |
Product Name |
Information |
| PC-42229 |
SYP-5
HIF-1 inhibitor
|
SYP-5 is a potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis. |
| PC-45387 |
Daprodustat
HIF-PHD inhibitor
|
Daprodustat (GSK1278863) is a potent, orally active HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.5, 22.2 and 2.2 nM for PHD1, PHD2 and PHD3, respectively. |
| PC-22355 |
DS44470011
HIF-PHD inhibitor
|
DS44470011 is a potent, selective hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with IC50 of 1.5 uM for HIF-PHD2, induces erythropoietin (EPO) release in Hep3B cells with EC50 of 8.4 uM. |
| PC-22353 |
PHD inhibitor IOX5
HIF-PHD inhibitor
|
IOX5 is a potent, selective HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 0.15 uM ((PHD2), does not inhibit other 2OG-dependent oxygenases (JMJD6, FIH, KDM6B etc.). |
| PC-22317 |
TC-S7009
HIF2α inhibitor
|
TC-S7009 is a specific inhibitor of HIF-2α with Kd of 81 nM, disrupts HIF-2α′s heterodimerization and DNA-binding activity, reducing the expression of HIF-2α-dependent genes. |
| PC-21729 |
FG-0041
HIF-PH inhibitor
|
FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase. |
| PC-21420 |
MO-2097
hnRNPA2B1 inhibitor
|
MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia. |
| PC-20172 |
BAY 87-2243
Mitochondrial complex I inhibitor
|
BAY 87-2243 (BAY87-2243) is a highly potent, selective inhibitor of hypoxia-induced gene activation (IC50=0.7 nM), directly inhibits mitochondrial complex I. |
| PC-49790 |
GSK1120360A
HIF-PHD inhibitor
|
GSK1120360A (GSK360A) is a potent, specific and orally active inhibitor of HIF PHD enzyme with pIC50 of 8.0/7.0/6.9 for PHD1/2/3, respectively. |
| PC-49374 |
ISCA2 inhibitor 25
ISCA2 inhibitor
|
ISCA2 inhibitor 25 is a selective, orally available small molecule inhibitor of HIF-2α with IC50 of 0.92 uM, decrease HIF-1/2α levels and induce ferroptosis by targeting Iron Sulfur Cluster Assembly 2 (ISCA2), a component of the late mitochondrial Iron Sulfur Cluster (L-ISC) assembly complex. |
| PC-72532 |
YQ-0629
HIF-2α inhibitor
|
YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM. |
| PC-72330 |
HIF inhibitor 208
HIF inhibitor
|
HIF inhibitor 208 is a small molecule inhibitor of HIF pathway with IC50 of 0.5 nM. |
