| Cat. No. |
Product Name |
Information |
| PC-60147 |
JTZ-951
HIF-PHD inhibitor
|
Enarodustat (JTZ-951) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2. |
| PC-45660 |
THS-044
HIF2α modulator
|
THS-044 is a low micromolar HIF2α PAS-B binding compound (Kd=2 uM). |
| PC-45555 |
KC7F2
HIF-1α inhibitor
|
KC7F2 is a small molecule HIF-1α translation inhibitor with IC50 of 20 uM. |
| PC-42474 |
PX-478
HIF-1α inhibitor
|
PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity. |
| PC-45759 |
HIF2α-IN-1
|
A potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay. . |
| PC-42346 |
Vadadustat
HIF-PHD inhibitor
|
Vadadustat (PG-1016548, AKB-6548) is a novel, potent, orally active HIF prolyl-4-hydroxylase (HIF-PHD) inhibitor with pKi of for PHD1, PHD2, and PHD3, respecitvely. |
| PC-42229 |
SYP-5
HIF-1 inhibitor
|
SYP-5 is a potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis. |
| PC-45387 |
Daprodustat
HIF-PHD inhibitor
|
Daprodustat (GSK1278863) is a potent, orally active HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.5, 22.2 and 2.2 nM for PHD1, PHD2 and PHD3, respectively. |
| PC-23636 |
Takeda-17
PHD inhibitor
|
Takeda-17 (PHD-1 inhibitor 17) is a potent, selective inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) with IC50 of 34 nM. |
| PC-23635 |
JPHM-2-167
PHD inhibitor
|
JPHM-2-167 is a potent, selective prolyl hydroxylase (PHD) inhibitor with IC50 of 1.7, 2.1 and 11 nM for PHD1, PHD2, and PHD3 respectively. |
| PC-23634 |
DDO-3055
PHD inhibitor
|
DDO-3055 is a potent, selective prolyl hydroxylase (PHD) inhibitor with IC50 of 64.2 nM toward PHD2, 29- and 2.6-fold selective over PHD1 and PHD3. |
| PC-23633 |
ISM012-042
HIF-PHD inhibitor
|
ISM012-042 is a potent, orally gut-restricted, selective PHD1 and PHD2 inhibitor with IC50 of 1.9 nM and 2.5 nM for PHD1 hydroxylase and PHD2 hydroxylase, respectively. |
