| Cat. No. |
Product Name |
Information |
| PC-45660 |
THS-044
HIF2α modulator
|
THS-044 is a low micromolar HIF2α PAS-B binding compound (Kd=2 uM). |
| PC-45555 |
KC7F2
HIF-1α inhibitor
|
KC7F2 is a small molecule HIF-1α translation inhibitor with IC50 of 20 uM. |
| PC-42474 |
PX-478
HIF-1α inhibitor
|
PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity. |
| PC-45759 |
HIF2α-IN-1
|
A potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay. . |
| PC-42346 |
Vadadustat
HIF-PHD inhibitor
|
Vadadustat (PG-1016548, AKB-6548) is a novel, potent, orally active HIF prolyl-4-hydroxylase (HIF-PHD) inhibitor with pKi of for PHD1, PHD2, and PHD3, respecitvely. |
| PC-42229 |
SYP-5
HIF-1 inhibitor
|
SYP-5 is a potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis. |
| PC-45387 |
Daprodustat
HIF-PHD inhibitor
|
Daprodustat (GSK1278863) is a potent, orally active HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.5, 22.2 and 2.2 nM for PHD1, PHD2 and PHD3, respectively. |
| PC-23246 |
ZG-2305
FIH inhibitor
|
ZG-2305 is a potent, and selective inhibitor of factor inhibiting HIF (FIH) with Ki of 79.6 nM, 38-fold selectivity over HIF prolyl hydroxylase PHD2. |
| PC-22855 |
DS-1093a
HIF-PHD inhibitor
|
DS-1093a is a potent, selective and oral hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with EC50 of 0.49 uM (EPO production in Hep3B cells). |
| PC-22692 |
HIF-PH inhibitor DMOG
HIF-PH inhibitor
|
DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF prolyl hydroxylase (HIF-PH), induces HIF-1α stabilisation and accmulation in vitro and in vivo. |
| PC-22621 |
N-oxalylglycine
2OG oxygenase inhibitor
|
N-oxalylglycine (NOG) is a broad-spectrum 2OG oxygenase inhibitor with IC50 of 0.36 uM, 12.3 uM, 11.1 uM and 0.15 uM for FIH, PHD2, aspartate/asparagine-β-hydroxylase (AspH) and JMJD5, respectively. |
| PC-22620 |
PHD2 inhibitor BNS
2OG oxygenase inhibitor
|
PHD2 inhibitor BNS is a broad-spectrum 2OG oxygenase inhibitor with IC50 of 0.3 uM, 0.11 uM, 3.4 uM and 0.25 uM for FIH, PHD2, aspartate/asparagine-β-hydroxylase (AspH) and JMJD5, respectively. |
