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Request The Product List ofHIF/HIF Prolyl-hydroxylase HIF/HIF Prolyl-hydroxylase

Cat. No. Product Name Information
PC-60317

PT2399

HIF-2α inhibitor

PT2399 (PT 2399, PT-2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain.
PC-60308

MK-8617

HIF-PHD inhibitor

MK-8617 is a potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.
PC-60148

JTZ-951 hydrochloride

HIF-PHD inhibitor

Enarodustat hydrochloride (JTZ-951 hydrochloride) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
PC-60147

JTZ-951

HIF-PHD inhibitor

Enarodustat (JTZ-951) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
PC-45660

THS-044

HIF2α modulator

THS-044 is a low micromolar HIF2α PAS-B binding compound (Kd=2 uM).
PC-45555

KC7F2

HIF-1α inhibitor

KC7F2 is a small molecule HIF-1α translation inhibitor with IC50 of 20 uM.
PC-42474

PX-478

HIF-1α inhibitor

PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity.
PC-45759

HIF2α-IN-1

A potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay. .
PC-42346

Vadadustat

HIF-PHD inhibitor

Vadadustat (PG-1016548, AKB-6548) is a novel, potent, orally active HIF prolyl-4-hydroxylase (HIF-PHD) inhibitor with pKi of for PHD1, PHD2, and PHD3, respecitvely.
PC-42229

SYP-5

HIF-1 inhibitor

SYP-5 is a potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis.
PC-45387

Daprodustat

HIF-PHD inhibitor

Daprodustat (GSK1278863) is a potent, orally active HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.5, 22.2 and 2.2 nM for PHD1, PHD2 and PHD3, respectively.
PC-24681

HIF-1α inhibitor LW6

HIF-1α inhibitor

HIF-1α inhibitor LW6 is a specific small compound that inhibits the accumulation of HIF-1α, decreases HIF-1α protein expression without affecting HIF-1β expression, has IC50 of 2.6 uM in HIF-1-mediated cell-based reporter assay in Hep3B cells.

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