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IDF-11774

Chemical Structure : IDF-11774

CAS No.: 1429054-28-3

IDF-11774 (IDF 11774;IDF11774)

Catalog No.: PC-60370Not For Human Use, Lab Use Only.

IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.

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Biological Activity

IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
IDF-11774 suppresses the mRNA expression of HIF-1 target genes VEGF and EPO but not HIF-1α.
IDF-11774 inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells.
IDF-11774 exhibits substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations.

Physicochemical Properties

M.Wt 368.521
Formula C23H32N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(4-((3r,5r,7r)-adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethan-1-one

References

1. Ban HS, et al. Bioconjug Chem. 2016 Aug 17;27(8):1911-20.

2. Ban HS, et al. Cell Death Dis. 2017 Jun 1;8(6):e2843.

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