Catalog No.: PC-60370Not For Human Use, Lab Use Only.
IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
IDF-11774 suppresses the mRNA expression of HIF-1 target genes VEGF and EPO but not HIF-1α.
IDF-11774 inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells.
IDF-11774 exhibits substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations.
