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Chemical Structure : IDF-11774
CAS No.: 1429054-28-3
Catalog No.: PC-60370Not For Human Use, Lab Use Only.
IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg (Free Sample) | $28 | In stock | |
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
IDF-11774 suppresses the mRNA expression of HIF-1 target genes VEGF and EPO but not HIF-1α.
IDF-11774 inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells.
IDF-11774 exhibits substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations.
| M.Wt | 368.521 | |
| Formula | C23H32N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(4-((3r,5r,7r)-adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethan-1-one |
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1. Ban HS, et al. Bioconjug Chem. 2016 Aug 17;27(8):1911-20.
2. Ban HS, et al. Cell Death Dis. 2017 Jun 1;8(6):e2843.
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